Single Dose Pharmacokinetic Study
Our research confirms that NASO B12 ensures quick and assured nasal absorption of Vitamin B12, and begins to correct the deficiency from the very first dose.
| Pharmacokinetic Parameters* | NASO B12 |
|---|---|
| Tmax (hr) | 0.20 ± 0.06 |
| Cmax (pg/mL) | 19779.47 ± 6726.28 |
| AUC0-t (hr*pg/mL) | 123399.31 ± 31342.86 |
| AUC0-inf (hr*pg/mL) | 243363.97 ± 120348.80 |
| t1/2 (hr) | 164.11 ± 162.61 |
Pharmacokinetic Comparison with Injection
| Brand | Dose (mcg) | Cmax (pg/mL) |
|---|---|---|
| NASO B12 | 500 | 19779 |
| IM Injection | 500 | 22400 |
- Through NASOMAX Technology, NASO B12 achieves Cmax 19779 pg/mL in just 12 minutes as compared to IM injection that takes 54 minutes to achieve Cmax of 22400 pg/mL
- A single-dose of NASO B12 nasal spray achieves comparable Cmax as claimed by IM Injection 500 mcg
- Our study proves that the absorption of Vitamin B12 achieved by NASO B12 is as good as Vitamin B12 injection
With a Single Dose of NASO B12, Levels were Maintained for 5 Days
- Vitamin B12 levels were maintained well above the sub-clinical cobalamin level (150-399 pg/mL) upon administering the first dose
- Based on this data, one weekly dose was selected for the maintenance phase of Vitamin B12 therapy with NASO B12
Clinical Trials
Our clinical trials involved 103 patients with Vitamin B12 deficiency, from both sexes in the age group of 18 to 55 years.
We found that NASO B12 is not only painless but also reliable & easy to self-administer. It is the best alternative for the treatment of Vitamin B12 deficiency, thus making the conventional treatment via tablets and injections obsolete.
At the end of the 7th dose, average serum B12 levels were found to be 717.15 pg/mL. Thereafter, one dose of 500 mcg (2 sprays) administered on a weekly basis for 4 consecutive weeks ensured the maintenance of serum levels of Vitamin B12.
Beyond Correcting Vitamin B12 Deficiency,
NASO B12 also Improves Haemoglobin Level
As suggested in these studies, in just 6 weeks, the haemoglobin level increased from 11.94 g/dL to 13.58 g/dL, a net gain of 1.64 g/dL & this was without iron supplementation.
Once the Haemoglobin levels approach 12.76 g/dL (Week 2) the reticulocyte count starts normalizing, but the rising trend in haemoglobin continues.